JWH-348

JWH-348 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure and Properties

JWH-348 has the chemical formula C₃₅H₂₅NO and a molecular weight of 371.48 g/mol. The structure consists of a naphthoyl group attached to an indole core, with a pentyl chain at the nitrogen atom of the indole. This configuration is similar to other compounds in the JWH series, which are named after the chemist John W. Huffman, who first synthesized them.

Pharmacology

JWH-348 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₁ receptor. This receptor is primarily found in the central nervous system, and its activation is responsible for the psychoactive effects associated with cannabinoids. The CB₂ receptor is more prevalent in the immune system and is involved in modulating immune responses.

Effects

The effects of JWH-348 are similar to those of THC, including euphoria, relaxation, altered perception of time, and increased appetite. However, synthetic cannabinoids like JWH-348 can also cause adverse effects such as anxiety, paranoia, tachycardia, and in some cases, psychosis.

Legal Status

Due to its potential for abuse and lack of medical use, JWH-348 is classified as a controlled substance in many countries. It is often included in the list of substances banned under synthetic cannabinoid legislation.

Research and Applications

JWH-348, like other synthetic cannabinoids, has been used in research to study the endocannabinoid system and to develop potential therapeutic agents. However, its use is limited due to safety concerns and legal restrictions.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• Endocannabinoid system