JWH-349

JWH-349

File:JWH-349 structure.png
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Chemical formula	CHNO
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JWH-349 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for the CB2 receptor over the CB1 receptor.

Chemical Structure and Properties

JWH-349 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The chemical structure of JWH-349 includes a naphthalene ring system, which is substituted with a methoxy group at the 4-position, and an indole moiety that is substituted with a pentyl chain at the 1-position. The full IUPAC name is 1-(4-Methoxynaphthalen-1-yl)-2-(1-pentylindol-3-yl)ethanone.

Pharmacology

JWH-349 is known to bind to the CB2 receptor with high affinity, making it a selective agonist for this receptor subtype. The CB2 receptor is primarily found in the peripheral tissues and is associated with the immune system. Activation of CB2 receptors does not produce the psychoactive effects typically associated with CB1 receptor activation, which is predominantly found in the central nervous system.

Receptor Binding

JWH-349 has been shown to have a higher affinity for the CB2 receptor compared to the CB1 receptor. This selectivity makes it a useful compound for studying the role of CB2 receptors in various physiological and pathological processes.

Effects

Due to its selectivity for the CB2 receptor, JWH-349 is primarily used in research settings to explore the potential therapeutic benefits of CB2 receptor activation, such as anti-inflammatory and immunomodulatory effects. It does not produce the psychoactive effects associated with CB1 receptor activation.

Legal Status

The legal status of JWH-349 varies by country. In some jurisdictions, it may be classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with recreational use and potential health risks.

Research Applications

JWH-349 is used in scientific research to investigate the role of CB2 receptors in various biological processes. It is particularly valuable in studies focused on the immune system, inflammation, and potential therapeutic applications of CB2 receptor agonists.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-349 is not well-established. Research is ongoing to determine its potential toxicological effects and long-term safety.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• CB1 receptor
• CB2 receptor
• JWH-018