JWH-358

JWH-358 is a synthetic cannabinoid that acts as a potent agonist at the CB1 receptor and CB2 receptor. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-358 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The full chemical name is (4-methoxy-1-naphthyl)(1-pentyl-1H-indol-3-yl)methanone. The presence of the methoxy group on the naphthalene ring is a distinguishing feature of this compound.

The molecular formula of JWH-358 is C₂₅H₂₅NO₂, and it has a molar mass of 371.47 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

JWH-358 acts as a full agonist at both the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system is involved in a variety of physiological processes including pain sensation, mood regulation, and appetite.

The binding affinity of JWH-358 for the CB1 receptor is high, which suggests that it can produce effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, the specific effects and potency can vary significantly due to differences in receptor binding and activation.

Legal Status

The legal status of JWH-358 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."

Research and Applications

JWH-358, like other synthetic cannabinoids, is primarily used in scientific research to better understand the endocannabinoid system and the effects of cannabinoid receptor activation. It has been used in studies to explore the therapeutic potential of cannabinoids, as well as their side effects and toxicology.

Safety and Toxicology

The safety profile of JWH-358 is not well-established, as it is not intended for human consumption. Synthetic cannabinoids have been associated with a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.

Also see

• Synthetic cannabinoids
• Endocannabinoid system
• CB1 receptor
• CB2 receptor
• JWH-018
• Cannabinoid receptor agonists