JWH-361

Synthetic cannabinoid

CaptionSynonyms

JWH-361

Drug Information
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Identifiers ATC Code DrugBank KEGG ChEBI ChEMBL		Chemical Data Molecular Weight

JWH-361 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-361 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a naphthalene ring system linked to an indole group via a ketone bridge. The presence of a methoxy group on the naphthalene ring and a pentyl chain on the indole nitrogen are characteristic features of this compound.

The molecular formula of JWH-361 is C₂₆H₂₇NO₂, and it has a molecular weight of 385.50 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

JWH-361 acts as a full agonist at the CB₁ and CB₂ cannabinoid receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood regulation, and appetite.

The binding affinity of JWH-361 for the CB₁ receptor is high, which contributes to its potent psychoactive effects. The compound mimics the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, but with potentially greater potency and efficacy.

Legal Status

The legal status of JWH-361 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is important for researchers and users to be aware of the legal implications of possessing or distributing this compound.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-361 is not well-established. There is limited data on its toxicity, long-term health effects, and potential for addiction. Users may experience adverse effects similar to those associated with other synthetic cannabinoids, such as anxiety, paranoia, and cardiovascular issues.

Research and Applications

JWH-361 is primarily used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. It serves as a tool for understanding the pharmacological properties of cannabinoids and their potential therapeutic applications.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system
• Tetrahydrocannabinol