JWH-387

JWH-387 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is a member of the naphthoylindole family of compounds, which were originally developed by Dr. John W. Huffman and his team at Clemson University for research purposes. JWH-387 is known for its high affinity for the CB1 receptor, which is primarily found in the central nervous system, and the CB2 receptor, which is primarily found in the peripheral tissues.

Chemical Structure and Properties

JWH-387 has the chemical formula C₂₅H₂₅NO₂ and a molecular weight of 371.47 g/mol. The structure of JWH-387 consists of a naphthoyl group attached to an indole core, with a methoxy group at the 4-position of the naphthalene ring and a pentyl chain at the 1-position of the indole ring. This structural configuration is responsible for its activity at the cannabinoid receptors.

Pharmacology

JWH-387 functions as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This interaction leads to the activation of the endocannabinoid system, which is involved in regulating various physiological processes such as mood, appetite, pain sensation, and memory. The potency and efficacy of JWH-387 at these receptors make it a subject of interest in both scientific research and recreational use.

Legal Status

Due to its psychoactive effects and potential for abuse, JWH-387, like many other synthetic cannabinoids, has been subject to legal restrictions in various countries. In the United States, it is classified as a Schedule I controlled substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess.

Health Effects and Risks

The use of JWH-387, particularly in unregulated products, poses significant health risks. Adverse effects may include tachycardia, hypertension, anxiety, paranoia, and hallucinations. Long-term use can lead to dependence and withdrawal symptoms. The lack of quality control in illicit products also increases the risk of contamination and unpredictable potency.

Research Applications

JWH-387 and other synthetic cannabinoids are used in research to study the endocannabinoid system and to develop potential therapeutic agents. They serve as tools to understand the pharmacological effects of cannabinoid receptor activation and to explore new treatments for conditions such as chronic pain, multiple sclerosis, and cancer.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system
• Controlled Substances Act