JWH-044

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JWH-044 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-044 is chemically classified as a naphthoylindole, with the IUPAC name (4-methylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone. The compound has a molecular formula of C₂₅H₂₅NO and a molecular weight of 359.48 g/mol. The structure consists of a naphthalene ring system substituted with a methanone group, which is linked to an indole ring with a pentyl chain.

Pharmacology

JWH-044 functions as a full agonist at the CB₁ and CB₂ cannabinoid receptors, which are part of the G protein-coupled receptor family. These receptors are primarily involved in the modulation of neurotransmitter release in the brain and peripheral tissues. The activation of these receptors by JWH-044 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Research and Development

JWH-044 was developed by John W. Huffman and his team at Clemson University as part of a series of compounds intended to explore the structure-activity relationships of cannabinoids. These compounds have been used extensively in research to better understand the endocannabinoid system and its role in various physiological processes.

Legal Status

The legal status of JWH-044 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it may be unregulated or fall under analog laws that control substances with similar structures or effects to known controlled substances.

Health Effects and Safety

The use of synthetic cannabinoids like JWH-044 can pose significant health risks. These compounds can produce unpredictable and sometimes severe effects, including tachycardia, hypertension, hallucinations, and psychosis. Long-term use may lead to dependence and withdrawal symptoms. Due to these risks, the recreational use of JWH-044 is discouraged.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• John W. Huffman
• Naphthoylindole