JWH-065

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JWH-065

Drug Information
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Identifiers ATC Code DrugBank UNII KEGG ChEBI ChEMBL		Chemical Data N

JWH-065 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and was first synthesized by John W. Huffman and his team at Clemson University.

Chemical Structure and Properties

JWH-065 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The compound has a molecular formula of C₂₄H₂₈O₂ and a molecular weight of 348.48 g/mol. Its structure includes a naphthalene ring system attached to an indole core, which is a common feature among many synthetic cannabinoids.

Pharmacology

JWH-065 acts as a full agonist at the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₁ receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of these receptors by JWH-065 leads to effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.

Effects and Usage

The effects of JWH-065 are similar to those of other synthetic cannabinoids and include euphoria, altered perception, and relaxation. However, due to its potency, the effects can be more intense and may include adverse reactions such as anxiety, paranoia, and tachycardia. JWH-065 has been used in research to study the endocannabinoid system and its role in various physiological processes.

Legal Status

The legal status of JWH-065 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, it may be considered an analogue of a Schedule I substance under the Federal Analogue Act.

Safety and Toxicology

The safety profile of JWH-065 is not well-established, as it has not been extensively studied in humans. Synthetic cannabinoids, in general, have been associated with a range of adverse effects, including cardiovascular and neurological issues. Users should exercise caution and be aware of the potential risks associated with its use.

Research and Development

JWH-065, like other synthetic cannabinoids, has been used in scientific research to better understand the cannabinoid receptor system and its implications in health and disease. Research continues to explore the therapeutic potential of cannabinoids and their synthetic analogues.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Naphthoylindole
• Tetrahydrocannabinol