JWH-102

Synthetic cannabinoid

CaptionSynonyms

JWH-102

Drug Information
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Identifiers ATC Code DrugBank KEGG ChEBI ChEMBL		Chemical Data N Molecular Weight

JWH-102 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist at both the CB₁ and CB₂ receptors. It was developed by Dr. John W. Huffman and his team in the late 1990s as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-102 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The compound has a molecular formula of C₂₅H₂₈O and a molecular weight of 344.49 g/mol. The structure of JWH-102 includes a naphthalene group attached to a dibenzopyran ring, which is a common feature in many synthetic cannabinoids.

Pharmacology

JWH-102 acts as a full agonist at the CB₁ and CB₂ receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood regulation, and appetite. The binding affinity of JWH-102 for the CB₁ receptor is relatively high, which contributes to its potent psychoactive effects.

Legal Status

The legal status of JWH-102 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, JWH-102 and other synthetic cannabinoids are often listed under the Controlled Substances Act as Schedule I substances.

Research and Applications

JWH-102, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the effects of cannabinoids on the human body. However, due to its potent effects and potential for abuse, its use is generally restricted to controlled laboratory settings.

Health Effects and Risks

The use of JWH-102 can lead to a range of effects, some of which may be harmful. These can include altered mental states, anxiety, paranoia, and in some cases, more severe psychological effects. The long-term health effects of JWH-102 are not well understood, and its use is generally discouraged outside of research settings.

Also see

• Synthetic cannabinoids
• John W. Huffman
• CB1 receptor
• CB2 receptor
• Endocannabinoid system