JWH-235

JWH-235

File:JWH-235 structure.png
IUPAC Name:	{{{IUPACName}}}
Other Names:
Identifiers
CAS Number
PubChem
ChemSpider
SMILES
InChI
InChIKey
StdInChI
StdInChIKey
Properties
Chemical formula	CHNO
Appearance
Density
Melting Point
Boiling Point
Solubility
Hazards
Main Hazards
Flash Point
Autoignition Temperature

JWH-235 is a synthetic cannabinoid that acts as a potent agonist at both the CB1 and CB2 cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive properties. JWH-235 was developed in the 1990s by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-235 has the chemical formula C24H26O and a molecular weight of 330.47 g/mol. The compound is characterized by a naphthyl group attached to a dibenzopyran ring system, which is a common feature among synthetic cannabinoids. The presence of the naphthyl group is believed to contribute to the compound's high affinity for cannabinoid receptors.

Pharmacology

JWH-235 acts as a full agonist at both CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-235 leads to the modulation of neurotransmitter release, resulting in effects such as altered perception, mood changes, and impaired memory.

The CB2 receptor, on the other hand, is primarily found in the peripheral tissues and is involved in immune system modulation. JWH-235's action on CB2 receptors suggests potential anti-inflammatory and immunomodulatory effects, although these have not been extensively studied.

Legal Status

The legal status of JWH-235 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In the United States, JWH-235 is listed as a Schedule I substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess.

Research and Applications

JWH-235, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. However, due to its psychoactive properties and potential for abuse, its use is restricted to laboratory settings.

Health Effects and Risks

The use of JWH-235, particularly in recreational settings, poses significant health risks. These include acute effects such as anxiety, paranoia, tachycardia, and hypertension. Chronic use may lead to dependence and withdrawal symptoms. The lack of regulation and quality control in the production of synthetic cannabinoids further increases the risk of adverse effects.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Naphthoylindole
• CB1 receptor
• CB2 receptor