JWH-239
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JWH-239 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-239 is characterized by its chemical structure, which includes a 1-(2-(4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl)ethyl)piperidine moiety. This structure is responsible for its high affinity and selectivity for the CB1 and CB2 cannabinoid receptors.
The compound has a molecular formula of C24H39NO2 and a molar mass of 373.57 g/mol. It is typically synthesized in a laboratory setting and is not found naturally.
Pharmacology[edit | edit source]
JWH-239 acts as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the therapeutic potential of CB2 receptor agonists, which are thought to have anti-inflammatory and analgesic properties without the psychoactive effects associated with CB1 receptor activation.
Legal Status[edit | edit source]
Due to its structural similarity to other synthetic cannabinoids, JWH-239 is often classified as a controlled substance in many jurisdictions. It is important for researchers to be aware of the legal status of JWH-239 in their country before conducting any studies.
Research and Applications[edit | edit source]
JWH-239 is primarily used in scientific research to study the effects of cannabinoid receptor activation. It has been used in various studies to explore the potential therapeutic benefits of targeting the CB2 receptor, particularly in the context of pain management and inflammation.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-239 is not well-established. It is important for researchers to exercise caution and adhere to safety protocols when handling this compound.
Also see[edit | edit source]
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