JWH-306
JWH-306 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-306 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The compound's full chemical name is (1-(2-(4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl)ethyl)-3-(1-naphthoyl)indole). It features a naphthoyl group attached to an indole core, with a dimethylheptyl side chain that contributes to its high affinity for cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-306 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-306 can lead to effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.
Legal Status[edit | edit source]
Due to its potential for abuse and lack of medical use, JWH-306, like many synthetic cannabinoids, has been classified as a controlled substance in several countries. In the United States, it is listed as a Schedule I substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess.
Research and Development[edit | edit source]
JWH-306 was initially synthesized for research purposes to better understand the interaction between synthetic cannabinoids and cannabinoid receptors. Studies involving JWH-306 have contributed to the broader understanding of how structural modifications can affect the potency and selectivity of cannabinoid receptor agonists.
Health Effects and Risks[edit | edit source]
The use of JWH-306, like other synthetic cannabinoids, can pose significant health risks. These compounds can produce severe adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and the lack of quality control in illicit products further increase the risk of overdose and toxic reactions.
Also see[edit | edit source]
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