JWH-314
JWH-314 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-314 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The compound has a molecular formula of C23H21NO2 and a molecular weight of 343.42 g/mol. The structure of JWH-314 includes a naphthoyl group attached to an indole core, which is a common feature among many synthetic cannabinoids.
Pharmacology[edit | edit source]
JWH-314 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of these receptors by JWH-314 can lead to effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-314 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids as a class.
Research and Development[edit | edit source]
JWH-314 was initially synthesized for research purposes to better understand the interaction between synthetic cannabinoids and cannabinoid receptors. Studies involving JWH-314 have contributed to the broader understanding of how structural modifications can affect the potency and selectivity of cannabinoid receptor agonists.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-314 is not well-established. There is limited data on its toxicity, but it is known that synthetic cannabinoids can cause a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.
Also see[edit | edit source]
- Synthetic cannabinoids
- Cannabinoid receptor
- John W. Huffman
- Naphthoylindole
- CB1 receptor
- CB2 receptor
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