JWH-340

JWH-340 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for the CB1 and CB2 receptors. JWH-340 was developed by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-340 is chemically classified as a naphthoylindole, with the IUPAC name 1-(2,2-dimethylpropyl)-3-(naphthalen-1-ylmethoxy)indole. The compound has a molecular formula of C24H25NO and a molar mass of 343.46 g/mol. The structure consists of an indole core with a naphthyl group attached via an ether linkage, and a dimethylpropyl group at the nitrogen atom of the indole.

Pharmacology

JWH-340 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system, where it modulates neurotransmitter release, leading to effects such as analgesia, euphoria, and altered perception. The CB2 receptor is mainly expressed in the immune system, and its activation is associated with anti-inflammatory effects.

Synthesis

The synthesis of JWH-340 involves the reaction of 1-naphthoyl chloride with 1-(2,2-dimethylpropyl)indole in the presence of a base, followed by the formation of the ether linkage with methanol. The process requires careful control of reaction conditions to ensure high yield and purity of the final product.

Legal Status

JWH-340, like many synthetic cannabinoids, is subject to legal restrictions in various countries due to its potential for abuse and lack of medical use. It is often included in legislation that bans synthetic cannabinoids as a class, rather than being specifically named.

Research and Applications

JWH-340 is primarily used in scientific research to study the effects of cannabinoid receptor activation. It serves as a tool for understanding the pharmacological properties of cannabinoids and their potential therapeutic applications. However, due to its potent psychoactive effects, it is not used in clinical settings.

Safety and Toxicology

The safety profile of JWH-340 has not been extensively studied, but it is assumed to have similar risks to other synthetic cannabinoids, including potential for addiction, adverse psychological effects, and toxicity at high doses. Users may experience symptoms such as anxiety, paranoia, and tachycardia.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Naphthoylindole