JWH-357
JWH-357 is a synthetic cannabinoid that acts as a potent agonist at both the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-357 is chemically classified as a naphthoylindole, with the systematic IUPAC name (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone. The compound has a molecular formula of C21H23NO2 and a molecular weight of 321.42 g/mol. The structure consists of a methoxyphenyl group attached to a pentylindole core, which is characteristic of many synthetic cannabinoids.
Pharmacology[edit | edit source]
JWH-357 functions as a full agonist at the CB1 and CB2 receptors, which are part of the G protein-coupled receptor family. These receptors are primarily involved in the modulation of neurotransmitter release in the central nervous system and immune system, respectively. The activation of these receptors by JWH-357 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-357 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Research and Applications[edit | edit source]
JWH-357, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and its role in various physiological processes. However, due to its psychoactive properties and potential for abuse, its use is restricted to controlled laboratory settings.
Health Effects and Risks[edit | edit source]
The use of JWH-357 outside of a research context can pose significant health risks. Adverse effects may include tachycardia, hypertension, anxiety, hallucinations, and psychosis. Long-term effects are not well-studied, but there is concern about potential neurotoxicity and other harmful outcomes.
Also see[edit | edit source]
- Synthetic cannabinoids
- Endocannabinoid system
- CB1 receptor
- CB2 receptor
- JWH-018
- Cannabinoid receptor agonists
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