JWH-187
JWH-187
JWH-187 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of Δ9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. JWH-187 was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-187 has the chemical formula C27H29NO and a molecular weight of 383.53 g/mol. The structure of JWH-187 includes a naphthoyl group attached to an indole core, which is a common feature among synthetic cannabinoids in the JWH series. The full IUPAC name of JWH-187 is 1-pentyl-3-(2-methoxyphenylacetyl)indole.
Pharmacology[edit | edit source]
JWH-187 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-187 leads to effects similar to those of THC, including altered perception, mood changes, and impaired cognitive function.
Legal Status[edit | edit source]
The legal status of JWH-187 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In the United States, JWH-187 and other synthetic cannabinoids have been placed under Schedule I of the Controlled Substances Act, making their manufacture, distribution, and possession illegal.
Health Effects and Risks[edit | edit source]
The use of JWH-187 and other synthetic cannabinoids has been associated with a range of adverse health effects. These can include anxiety, paranoia, tachycardia, hypertension, and in severe cases, psychosis and seizures. The variability in potency and the presence of unknown adulterants in products containing synthetic cannabinoids further increase the risk of harmful effects.
Research and Applications[edit | edit source]
While JWH-187 itself is not used in clinical practice, research into synthetic cannabinoids has provided valuable insights into the functioning of the endocannabinoid system. This research has potential applications in the development of new therapeutic agents for conditions such as chronic pain, multiple sclerosis, and epilepsy.
Also see[edit | edit source]
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