JWH-215
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Chemical Data
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JWH-215 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the JWH series of synthetic cannabinoids, which were developed by Dr. John W. Huffman in the 1990s for research purposes.
Chemical Structure and Properties[edit | edit source]
JWH-215 is chemically classified as a naphthoylindole, a class of compounds that are structurally similar to the active components of cannabis, such as tetrahydrocannabinol (THC). The compound has a molecular formula of C₄H₃₉NO₂ and a molecular weight of 373.57 g/mol.
Pharmacology[edit | edit source]
JWH-215 is known to bind to both CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This receptor selectivity makes it of interest in research focused on the development of anti-inflammatory and analgesic drugs, as CB2 receptors are primarily located in the peripheral tissues and are involved in immune system modulation.
Mechanism of Action[edit | edit source]
JWH-215 acts as a full agonist at the cannabinoid receptors, mimicking the effects of naturally occurring cannabinoids. Upon binding to these receptors, JWH-215 can modulate neurotransmitter release in the brain, leading to effects such as altered perception, mood changes, and potential therapeutic effects like pain relief.
Legal Status[edit | edit source]
The legal status of JWH-215 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. Researchers must often obtain special licenses to study this compound.
Research and Applications[edit | edit source]
JWH-215 has been used in scientific research to better understand the endocannabinoid system and to explore potential therapeutic applications of cannabinoid receptor agonists. Studies have investigated its effects on pain, inflammation, and neuroprotection.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-215 is not well-established. Potential adverse effects may include anxiety, tachycardia, and hallucinations. Long-term effects are unknown, and caution is advised when handling this compound in a research setting.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
