5F-AMPPPCA
5F-AMPPPCA is a synthetic cannabinoid that has been identified as a designer drug. It is a potent agonist of the cannabinoid receptors and is structurally related to other synthetic cannabinoids such as 5F-ADB and 5F-MDMB-PINACA.
Chemical Structure and Properties[edit | edit source]
5F-AMPPPCA belongs to the indole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by a 5-fluoropentyl chain attached to the nitrogen atom of the indole core, and an amide linkage to a phenyl ring. The IUPAC name for 5F-AMPPPCA is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide.
Molecular Formula[edit | edit source]
The molecular formula of 5F-AMPPPCA is C23H30FN3O2.
Molecular Weight[edit | edit source]
The molecular weight of 5F-AMPPPCA is 399.51 g/mol.
Pharmacology[edit | edit source]
5F-AMPPPCA acts as a full agonist at the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood, and memory.
Binding Affinity[edit | edit source]
The binding affinity of 5F-AMPPPCA for the CB1 receptor is high, which contributes to its potent psychoactive effects. The exact binding affinities for CB1 and CB2 receptors are not well-documented in the literature, but similar compounds have shown nanomolar affinities.
Legal Status[edit | edit source]
The legal status of 5F-AMPPPCA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids as a class.
Health Effects and Risks[edit | edit source]
The use of 5F-AMPPPCA is associated with a range of adverse health effects. These can include:
- Tachycardia
- Hypertension
- Anxiety
- Hallucinations
- Seizures
Due to its potency and the variability in synthetic cannabinoid products, the risk of overdose and severe adverse effects is significant.
Detection in Biological Samples[edit | edit source]
5F-AMPPPCA can be detected in biological samples using techniques such as gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods are used in forensic and clinical toxicology to confirm exposure to the substance.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
