AM-2213

A synthetic cannabinoid

AM-2213 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of a class of compounds that are often used in scientific research to study the endocannabinoid system.

Chemical Structure and Properties

AM-2213 is chemically classified as an indole-based synthetic cannabinoid. Its IUPAC name is (1-(5-fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone. The compound features a fluoropentyl chain attached to the indole core, which is a common structural motif in many synthetic cannabinoids.

The presence of the fluorine atom in the pentyl chain is believed to enhance the compound's binding affinity to the cannabinoid receptors, particularly CB1 and CB2. This modification can also affect the compound's metabolic stability and pharmacokinetic properties.

Pharmacology

AM-2213 acts as a full agonist at the CB1 and CB2 receptors, which are part of the G protein-coupled receptor family. These receptors are primarily involved in the modulation of neurotransmitter release in the brain and are responsible for the psychoactive effects of tetrahydrocannabinol (THC), the main active component of cannabis.

The activation of CB1 receptors by AM-2213 can lead to effects such as altered mood, perception, and cognition, similar to those produced by THC. However, synthetic cannabinoids like AM-2213 can be significantly more potent than THC, leading to a higher risk of adverse effects.

Legal Status

The legal status of AM-2213 varies by country. In many jurisdictions, synthetic cannabinoids are controlled substances due to their potential for abuse and lack of medical use. Researchers must often obtain special licenses to study these compounds.

Research Applications

AM-2213 is primarily used in scientific research to explore the endocannabinoid system and to develop new therapeutic agents that target cannabinoid receptors. Studies involving AM-2213 can help elucidate the role of cannabinoid receptors in various physiological and pathological processes.

Safety and Toxicology

The safety profile of AM-2213 is not well-established, as it is primarily used in research settings. However, synthetic cannabinoids in general have been associated with a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Tetrahydrocannabinol
• Cannabis