AM-881
A synthetic cannabinoid
AM-881 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is a member of the indole-3-carboxamide family of synthetic cannabinoids, which are known for their high affinity and selectivity for the CB1 and CB2 receptors.
Chemical Structure and Properties[edit | edit source]
AM-881 is chemically classified as a cyclopropylindole derivative. Its IUPAC name is (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone. The compound features a fluoropentyl chain attached to the indole core, which is a common structural motif in many synthetic cannabinoids. The presence of the fluorine atom is thought to enhance the lipophilicity and metabolic stability of the compound.
Pharmacology[edit | edit source]
AM-881 acts as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by AM-881 leads to the modulation of neurotransmitter release, resulting in effects such as euphoria, altered perception, and relaxation.
Legal Status[edit | edit source]
The legal status of AM-881 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Potential Risks and Side Effects[edit | edit source]
The use of AM-881, like other synthetic cannabinoids, can pose significant health risks. Adverse effects may include anxiety, paranoia, tachycardia, and in severe cases, psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids further increases the risk of harmful effects.
Research and Applications[edit | edit source]
While AM-881 is primarily known for its recreational use, it has also been studied in research settings to better understand the endocannabinoid system and the pharmacological effects of cannabinoid receptor activation. However, due to its potential for abuse, research is often limited and highly regulated.
Also see[edit | edit source]
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