JWH-188
JWH-188 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-188 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a 1-pentyl-3-(4-methoxy-1-naphthoyl)indole framework. The presence of the methoxy group on the naphthalene ring is a distinguishing feature of JWH-188 compared to other compounds in the JWH series.
Pharmacology[edit | edit source]
JWH-188 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of these receptors by JWH-188 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-188 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Potential Risks and Side Effects[edit | edit source]
As with other synthetic cannabinoids, the use of JWH-188 can pose significant health risks. These may include tachycardia, hypertension, hallucinations, anxiety, and psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids further increases the risk of adverse effects.
Research and Applications[edit | edit source]
JWH-188, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse, its use is restricted in many research settings.
Also see[edit | edit source]
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