JWH-201

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JWH-201 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-201 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure is characterized by a naphthalene group attached to an indole core, with a fluoropentyl chain at the nitrogen atom of the indole. The IUPAC name for JWH-201 is (1-(5-fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone.

The molecular formula of JWH-201 is C₂₅H₂₄FNO, and it has a molecular weight of 373.47 g/mol. The presence of the fluorine atom in the pentyl chain is a distinguishing feature of this compound.

Pharmacology

JWH-201 acts as a full agonist at the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system. These receptors are G-protein coupled receptors that mediate the effects of cannabinoids in the body. The activation of these receptors by JWH-201 can lead to a variety of physiological and psychoactive effects.

The potency of JWH-201 at these receptors is significant, making it a subject of interest in both research and recreational contexts. However, its use outside of controlled research settings is often associated with adverse effects due to its high potency and lack of regulation.

Legal Status

The legal status of JWH-201 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."

Health Effects and Risks

The use of JWH-201, like other synthetic cannabinoids, can pose significant health risks. These compounds can produce effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis, but often with greater intensity and unpredictability. Adverse effects may include anxiety, paranoia, tachycardia, and in severe cases, psychosis or seizures.

Research Applications

JWH-201 and other synthetic cannabinoids are used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. They serve as tools to explore receptor binding, signal transduction, and the potential therapeutic applications of cannabinoids.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• JWH-073