JWH-224
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JWH-224 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team in the early 2000s as part of research into the structure-activity relationships of cannabinoid compounds.
Chemical Structure and Properties[edit | edit source]
JWH-224 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure is characterized by a naphthyl group attached to an indole core, with a piperidine ring and a cyanophenyl group. The IUPAC name for JWH-224 is (1-(1-(2-(4-cyanophenyl)ethyl)piperidin-4-yl)-1H-indol-3-yl)(naphthalen-1-yl)methanone.
Pharmacology[edit | edit source]
JWH-224 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB2 receptor. This receptor selectivity profile is similar to other compounds in the JWH series, which are known for their potent psychoactive effects. The activation of these receptors by JWH-224 leads to a range of effects, including analgesia, sedation, and alterations in mood and perception.
Legal Status[edit | edit source]
The legal status of JWH-224 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, many synthetic cannabinoids, including JWH-224, are listed as Schedule I substances under the Controlled Substances Act.
Potential Risks and Side Effects[edit | edit source]
The use of JWH-224, like other synthetic cannabinoids, can lead to adverse effects such as anxiety, paranoia, tachycardia, and in severe cases, psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids increases the risk of contamination and unpredictable potency, which can exacerbate these side effects.
Research and Applications[edit | edit source]
JWH-224, along with other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. However, due to its potential for abuse, its use is restricted to laboratory settings.
Also see[edit | edit source]
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