JWH-240

JWH-240 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-240 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its IUPAC name is (4-methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone. The compound has a molecular formula of C₂₅H₂₅NO₂ and a molar mass of 371.47 g/mol.

The structure of JWH-240 consists of a naphthalene ring system substituted with a methoxy group at the 4-position, and an indole moiety linked via a ketone bridge. The indole is further substituted with a pentyl chain at the nitrogen atom.

Pharmacology

JWH-240 acts as a full agonist at the CB₁ and CB₂ cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-240 for the CB₁ receptor is reported to be in the low nanomolar range, indicating high potency. This makes it significantly more potent than Δ9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status

Due to its potent psychoactive effects and potential for abuse, JWH-240, along with many other synthetic cannabinoids, has been classified as a controlled substance in several countries. In the United States, it is listed as a Schedule I substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess.

Research and Applications

JWH-240, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents. However, its use is limited due to its legal status and potential for adverse effects.

Health Effects and Risks

The use of JWH-240 and similar synthetic cannabinoids has been associated with a range of adverse health effects. These can include tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and the lack of quality control in illicit products further increase the risk of harmful effects.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system
• Δ9-tetrahydrocannabinol