JWH-265
Synthetic cannabinoid
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JWH-265 is a synthetic cannabinoid that acts as a selective agonist for the cannabinoid receptors. It was developed by John W. Huffman and his team in the late 1990s as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-265 belongs to the class of compounds known as naphthoylindoles, which are characterized by a naphthalene group linked to an indole group. The chemical structure of JWH-265 is defined by the presence of a 1,1-dimethylheptyl side chain, which is a common feature in many potent synthetic cannabinoids. This side chain contributes to the compound's high affinity for the cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-265 is a potent agonist of the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. The activation of these receptors by JWH-265 leads to a range of effects that mimic those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Mechanism of Action[edit | edit source]
The mechanism of action of JWH-265 involves the binding to and activation of the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including pain sensation, mood, appetite, and memory.
Potential Applications[edit | edit source]
While JWH-265 and similar synthetic cannabinoids have been primarily used in research settings, there is interest in their potential therapeutic applications. These compounds could be used to develop new treatments for conditions such as chronic pain, multiple sclerosis, and cancer-related symptoms.
Legal Status[edit | edit source]
The legal status of JWH-265 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must obtain special licenses to study this compound.
Safety and Toxicity[edit | edit source]
The safety profile of JWH-265 is not well-established, as it has not been extensively studied in humans. However, synthetic cannabinoids in general have been associated with adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
