JWH-267

JWH-267 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive effects similar to those of tetrahydrocannabinol (THC), the primary active component of cannabis.

Chemical Structure and Properties

JWH-267 is chemically classified as a naphthoylindole, with the full chemical name being 1-pentyl-3-(4-methoxy-1-naphthoyl)indole. The compound has a molecular formula of C25H25NO2 and a molecular weight of 371.47 g/mol.

The structure of JWH-267 includes a naphthalene ring, which is a bicyclic aromatic hydrocarbon, attached to an indole group. The indole is further substituted with a pentyl chain at the nitrogen atom and a methoxy group at the 4-position of the naphthalene ring.

Pharmacology

JWH-267 acts as a full agonist at the cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2). These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, appetite, and pain sensation.

The binding affinity of JWH-267 for the CB1 receptor is high, which contributes to its potent psychoactive effects. The compound's interaction with the CB2 receptor is also significant, although the physiological implications of this interaction are less well understood compared to CB1.

Legal Status

The legal status of JWH-267 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In the United States, JWH-267 and other synthetic cannabinoids are often listed under Schedule I of the Controlled Substances Act.

Potential Risks and Side Effects

The use of JWH-267, like other synthetic cannabinoids, can lead to a range of adverse effects. These may include anxiety, paranoia, tachycardia, hypertension, and in severe cases, psychosis. The long-term health effects of JWH-267 are not well studied, but there is concern about its potential to cause harm due to its high potency and full agonist activity at cannabinoid receptors.

Research and Applications

JWH-267 is primarily used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. It serves as a tool for understanding the pharmacological properties of synthetic cannabinoids and their potential therapeutic applications.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor type 1
• Cannabinoid receptor type 2
• JWH-018
• Endocannabinoid system