JWH-305

JWH-305_structure.png Chemical structure of JWH-305

JWH-305 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-305 is chemically classified as a naphthoylindole, with the IUPAC name (2-(2-Methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone). The compound has a molecular formula of C₂₂H₂₅NO₂ and a molecular weight of 335.44 g/mol. The structure consists of a pentyl chain attached to the indole core, which is a common feature among synthetic cannabinoids, contributing to its lipophilicity and ability to cross the blood-brain barrier.

Pharmacology

JWH-305 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₁ receptor. This receptor is primarily located in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB₁ receptors by JWH-305 leads to the modulation of neurotransmitter release, affecting processes such as pain sensation, mood, and appetite.

Legal Status

Due to its psychoactive properties and potential for abuse, JWH-305, like many other synthetic cannabinoids, has been subject to legal restrictions in various countries. It is often included in the list of controlled substances under analog laws, which aim to regulate compounds that are structurally similar to already controlled substances.

Research and Applications

JWH-305 was initially synthesized for research purposes to better understand the endocannabinoid system and the role of cannabinoid receptors in physiological and pathological processes. It has been used in laboratory settings to study receptor binding and signal transduction pathways. However, due to its potential for abuse, its use is now largely restricted to controlled research environments.

Health Effects and Risks

The use of JWH-305, particularly in unregulated settings, poses significant health risks. As a potent agonist of the CB₁ receptor, it can cause severe psychoactive effects, including anxiety, paranoia, and hallucinations. Long-term use may lead to dependence and withdrawal symptoms. Additionally, the lack of quality control in illicit products containing JWH-305 increases the risk of contamination and adverse reactions.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• CB1 receptor
• CB2 receptor