JWH-316

JWH-316 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive properties and are often used in research settings to study the endocannabinoid system.

Chemical Structure and Properties

JWH-316 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The chemical structure of JWH-316 includes a naphthalene group attached to an indole core, with a specific substitution pattern that confers its activity at cannabinoid receptors.

The IUPAC name for JWH-316 is (1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone. Its molecular formula is C₂₅H₂₃NO, and it has a molecular weight of 353.46 g/mol.

Pharmacology

JWH-316 acts as a full agonist at the CB₁ and CB₂ cannabinoid receptors, which are part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including mood, appetite, pain sensation, and memory.

The binding affinity of JWH-316 for the CB₁ receptor is high, which contributes to its potent psychoactive effects. The compound's activity at the CB₂ receptor is also significant, although the physiological implications of this are less well understood.

Legal Status

The legal status of JWH-316 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must obtain special licenses to study JWH-316 and related compounds.

Research Applications

JWH-316 is primarily used in scientific research to explore the function of the endocannabinoid system and to develop potential therapeutic agents. Studies involving JWH-316 can help elucidate the mechanisms of cannabinoid receptor activation and the effects of synthetic cannabinoids on the brain and body.

Safety and Toxicology

The safety profile of JWH-316 is not well established, as it is not intended for human consumption. However, synthetic cannabinoids in general have been associated with a range of adverse effects, including anxiety, paranoia, tachycardia, and in severe cases, psychosis and organ damage.

Also see

• Synthetic cannabinoids
• Endocannabinoid system
• Cannabinoid receptor
• JWH-018
• Naphthoylindole