JWH-346
Overview[edit | edit source]
JWH-346 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive effects similar to those of THC, the active component in cannabis.
Chemical Structure and Properties[edit | edit source]
JWH-346 is chemically classified as a naphthoylindole, with the systematic name 1-pentyl-3-(4-methoxy-1-naphthoyl)indole. Its molecular formula is C25H25NO2, and it has a molecular weight of 371.48 g/mol. The compound features a naphthalene ring system attached to an indole core, with a methoxy group at the 4-position of the naphthalene ring and a pentyl chain at the indole nitrogen.
Pharmacology[edit | edit source]
JWH-346 acts as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This receptor is primarily located in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-346 leads to the modulation of neurotransmitter release, resulting in altered perception, mood, and cognition.
Legal Status[edit | edit source]
The legal status of JWH-346 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Health Effects and Risks[edit | edit source]
The use of JWH-346, like other synthetic cannabinoids, can pose significant health risks. These may include tachycardia, hypertension, anxiety, paranoia, and hallucinations. In severe cases, it can lead to seizures, psychosis, and renal failure. The long-term effects of JWH-346 are not well-studied, but chronic use of synthetic cannabinoids has been associated with cognitive impairment and mental health disorders.
Research and Applications[edit | edit source]
While JWH-346 is primarily known for its recreational use, it has been studied in research settings to understand the role of cannabinoid receptors in the body. These studies can provide insights into potential therapeutic applications of cannabinoids, such as in the treatment of pain, inflammation, and neurological disorders.
Also see[edit | edit source]
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