JWH-350

Synthetic cannabinoid

JWH-350 is a synthetic cannabinoid that acts as a potent agonist at both the CB₁ and CB₂ receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-350 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a naphthalene group attached to an indole core, with a morpholine group linked via an ethyl chain. The IUPAC name for JWH-350 is (1-(2-Morpholin-4-ylethyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone.

The compound has a molecular formula of C₂₅H₂₄N₂O₂ and a molecular weight of 384.47 g/mol. It is typically synthesized in a laboratory setting and is not found naturally in any plant or organism.

Pharmacology

JWH-350 acts as a full agonist at the CB₁ and CB₂ receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood regulation, and appetite.

The binding affinity of JWH-350 for the CB₁ receptor is relatively high, which contributes to its potent psychoactive effects. The compound's interaction with the CB₂ receptor is also significant, which may influence immune system responses.

Legal Status

The legal status of JWH-350 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, for example, it may be considered an analogue of other controlled synthetic cannabinoids, making it illegal under the Federal Analogue Act.

Research and Applications

JWH-350, like other synthetic cannabinoids, was initially developed for research purposes. It has been used in scientific studies to better understand the endocannabinoid system and the effects of cannabinoids on the human body. However, due to its potent effects and potential for abuse, its use is now heavily regulated.

Health Effects and Risks

The use of JWH-350 can lead to a range of effects, some of which may be harmful. These can include altered mental states, anxiety, paranoia, and in some cases, more severe psychological effects. The long-term health effects of synthetic cannabinoids like JWH-350 are not well understood, but there is concern about their potential to cause harm.

Also see

• Synthetic cannabinoids
• Endocannabinoid system
• CB1 receptor
• CB2 receptor
• JWH-018