JWH-73
| JWH-073_structure.png | |
JWH-073 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by Dr. John W. Huffman and his team at Clemson University as part of research into the structure and function of the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-073 is chemically classified as a naphthoylindole, with the IUPAC name (1-butyl-1H-indol-3-yl)-1-naphthalenylmethanone. It has a molecular formula of C23H21NO and a molecular weight of 327.42 g/mol. The compound features a naphthalene group attached to an indole core, with a butyl chain at the nitrogen atom of the indole.
Pharmacology[edit | edit source]
JWH-073 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system, and its activation is associated with the psychoactive effects of cannabinoids. JWH-073 has been shown to produce effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-073 varies by country. In the United States, it was classified as a Schedule I controlled substance under the Controlled Substances Act in 2011, making it illegal to manufacture, distribute, or possess. Other countries have similarly regulated JWH-073 due to concerns about its potential for abuse and lack of accepted medical use.
Health Effects and Risks[edit | edit source]
The use of JWH-073 has been associated with a range of adverse health effects, including tachycardia, hypertension, hallucinations, and seizures. As a synthetic cannabinoid, it can be more potent than natural cannabinoids, leading to a higher risk of overdose and severe side effects. Long-term use may also lead to addiction and psychosis.
Research and Applications[edit | edit source]
JWH-073, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse and adverse effects, its use is limited to controlled laboratory settings.
Also see[edit | edit source]
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