17-Acetoxyprogesterone

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17-Acetoxyprogesterone


17-Acetoxyprogesterone (also known as 17-AP) is a steroid and progestogen that is related to progesterone. It is a derivative of progesterone and is a potent progestogen, but has no androgenic or estrogenic activity.

Chemistry[edit | edit source]

17-Acetoxyprogesterone, also known as 17-AP, is a synthetic, steroidal progestogen of the pregnane group. It is an acetate ester of progesterone, which itself is a naturally occurring progestogen.

Pharmacology[edit | edit source]

17-Acetoxyprogesterone acts as a potent progestogen, but unlike progesterone, it has no androgenic or estrogenic activity. It is used in medicine as a progestogen in hormone replacement therapy for menopausal women, and in contraceptive hormonal preparations.

Medical uses[edit | edit source]

17-Acetoxyprogesterone is used in medicine as a progestogen in hormone replacement therapy for menopausal women, and in contraceptive hormonal preparations. It is also used in the treatment of endometriosis, a condition in which the tissue that normally lines the uterus grows outside of it.

Side effects[edit | edit source]

Like all progestogens, 17-Acetoxyprogesterone can cause a variety of side effects, including mood swings, weight gain, breast tenderness, and menstrual irregularities.

See also[edit | edit source]




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Contributors: Prab R. Tumpati, MD