AM-1902

Synthetic cannabinoid

AM-1902 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the AM series of cannabinoids, which were developed by the research group led by Alexandros Makriyannis. These compounds are primarily used in scientific research to study the endocannabinoid system and its role in various physiological processes.

Chemical Structure and Properties

AM-1902 is chemically classified as an indole-based synthetic cannabinoid. Its structure includes a 5-fluoropentyl chain, which is a common feature in many synthetic cannabinoids, contributing to its high affinity for cannabinoid receptors. The compound also contains a 4-methylnaphthalen-1-yl group, which is linked to the indole core via a ketone bridge.

The molecular formula of AM-1902 is C₂₅H₂₄FN₁O₁, and it has a molecular weight of approximately 373.47 g/mol. The presence of the fluorine atom in the pentyl chain is believed to enhance the compound's lipophilicity and receptor binding affinity.

Pharmacology

AM-1902 functions as a full agonist at the CB₁ and CB₂ receptors, which are part of the G protein-coupled receptor family. These receptors are primarily located in the central nervous system and immune system, respectively. Activation of these receptors by AM-1902 can lead to a variety of effects, including alterations in mood, perception, and cognition, as well as potential anti-inflammatory and analgesic effects.

The potency and efficacy of AM-1902 at cannabinoid receptors make it a valuable tool for researchers studying the endocannabinoid system and its potential therapeutic applications. However, due to its potency, it also poses significant risks if misused, leading to adverse effects such as tachycardia, anxiety, and psychosis.

Legal Status

The legal status of AM-1902 varies by jurisdiction. In many countries, synthetic cannabinoids are controlled substances due to their potential for abuse and adverse health effects. Researchers must comply with local regulations when handling and studying AM-1902.

Research Applications

AM-1902 is primarily used in preclinical research to explore the pharmacological effects of cannabinoid receptor activation. Studies involving AM-1902 can provide insights into the potential therapeutic uses of cannabinoids, such as in the treatment of chronic pain, inflammation, and neurological disorders.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of AM-1902 is not well-established. It is important for researchers to exercise caution and adhere to safety protocols when handling this compound. Potential toxicological effects include cardiovascular and neurological disturbances, which necessitate further investigation.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• AM-2201
• JWH-018