AM-661

A synthetic cannabinoid compound

AM-661 is a synthetic cannabinoid compound that acts as a potent agonist at the cannabinoid receptors. It is a member of the AM cannabinoid series, which are analogs of the classical cannabinoids such as THC (tetrahydrocannabinol), the primary psychoactive component of cannabis.

Chemical Structure and Properties

AM-661 is chemically classified as a dibenzopyran derivative. Its structure is characterized by a dibenzopyran core with a 1,1-dimethylheptyl side chain, which is a common feature in many synthetic cannabinoids that enhances their potency and affinity for cannabinoid receptors.

The IUPAC name of AM-661 is (6aR,10aR)-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran. This compound has a molecular formula of C₃₅H₅₀O₃ and a molecular weight of 518.77 g/mol.

Pharmacology

AM-661 acts as a full agonist at the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system. The CB1 receptor is primarily found in the central nervous system, while the CB2 receptor is more prevalent in the immune system.

The activation of these receptors by AM-661 can lead to a variety of effects, including analgesia, anti-inflammatory effects, and psychoactive effects similar to those produced by THC. However, due to its synthetic nature and high potency, AM-661 may also produce more pronounced side effects.

Research and Applications

AM-661, like many synthetic cannabinoids, is primarily used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. It is not approved for medical use in humans and is often used in laboratory settings to understand the pharmacological properties of cannabinoids.

Legal Status

The legal status of AM-661 varies by country. In many jurisdictions, synthetic cannabinoids are controlled substances due to their potential for abuse and lack of medical use. Researchers must obtain appropriate licenses to work with these compounds.

Safety and Toxicology

The safety profile of AM-661 is not well-established, as it is primarily used in research settings. Synthetic cannabinoids have been associated with adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. Caution is advised when handling these compounds in a laboratory environment.

Also see

• Cannabinoid receptor
• Synthetic cannabinoids
• Endocannabinoid system
• AM cannabinoid
• THC