CUMYL-TSINACA

Synthetic cannabinoid

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CUMYL-TSINACA

Drug Information
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Identifiers ATC Code DrugBank KEGG ChEBI ChEMBL		Chemical Data Molecular Weight

CUMYL-TSINACA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors, which are part of the endocannabinoid system in the human body. This compound is part of a class of synthetic cannabinoids that are often found in products marketed as "herbal incense" or "legal highs."

Chemical Structure and Properties

CUMYL-TSINACA is chemically classified as an indazole-based synthetic cannabinoid. Its IUPAC name is 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide. The compound has a molecular formula of C₂₃H₂₆FN₃O and a molecular weight of 379.47 g/mol.

The structure of CUMYL-TSINACA includes a fluorinated pentyl chain, which is a common feature in many synthetic cannabinoids, contributing to its high potency and affinity for cannabinoid receptors.

Pharmacology

CUMYL-TSINACA acts as a full agonist at the CB1 receptor and CB2 receptor, which are the primary receptors of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood, and memory.

The activation of CB1 receptors by CUMYL-TSINACA can lead to psychoactive effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis. However, synthetic cannabinoids like CUMYL-TSINACA can be significantly more potent than THC, leading to increased risk of adverse effects.

Legal Status

The legal status of CUMYL-TSINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Regulatory agencies often ban entire classes of synthetic cannabinoids to prevent the proliferation of new variants.

Health Risks and Toxicity

The use of CUMYL-TSINACA has been associated with a range of adverse effects, including anxiety, paranoia, tachycardia, and in severe cases, seizures and death. The variability in potency and the presence of unknown impurities in products containing synthetic cannabinoids further increase the risk of toxicity.

Detection in Biological Samples

CUMYL-TSINACA and its metabolites can be detected in biological samples using advanced analytical techniques such as liquid chromatography-mass spectrometry (LC-MS). These methods are crucial for forensic investigations and clinical toxicology.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Designer drugs
• Legal status of synthetic cannabinoids