JWH-036
JWH-036 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds and was first synthesized by John W. Huffman and his team at Clemson University.
Chemical Structure and Properties[edit | edit source]
JWH-036 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a naphthalene group attached to an indole core, with a pentyl chain at the nitrogen atom of the indole. The IUPAC name for JWH-036 is (1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone.
Pharmacology[edit | edit source]
JWH-036 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-036 leads to effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-036 varies by country. In the United States, it is classified as a Schedule I controlled substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess. Other countries have similar restrictions due to its potential for abuse and lack of accepted medical use.
Potential Risks and Side Effects[edit | edit source]
As with other synthetic cannabinoids, JWH-036 can pose significant health risks. These may include tachycardia, hypertension, hallucinations, and psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids increases the risk of contamination and unpredictable effects.
Research and Applications[edit | edit source]
JWH-036, like other synthetic cannabinoids, has been used in research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse and adverse effects, its use is limited to controlled laboratory settings.
Also see[edit | edit source]
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