JWH-165

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JWH-165 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist at both the CB₁ and CB₂ receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-165 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure is characterized by a 1-naphthalenylmethanone core with a 2-methyl-1-propyl substitution on the indole ring. The molecular formula of JWH-165 is C₂₃H₂₁NO, and it has a molecular weight of 327.42 g/mol.

Pharmacology

JWH-165 acts as a full agonist at the CB₁ and CB₂ receptors, with a higher affinity for the CB₂ receptor. This receptor selectivity profile is similar to other compounds in the JWH series, which are known for their potent cannabinoid receptor activity. The activation of these receptors by JWH-165 leads to a range of physiological effects, including analgesia, anti-inflammatory effects, and psychoactive effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status

The legal status of JWH-165 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, many synthetic cannabinoids, including those in the JWH series, are classified as Schedule I substances under the Controlled Substances Act.

Research and Applications

JWH-165, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse and adverse effects, its use is generally limited to controlled laboratory settings.

Health Effects and Risks

The use of JWH-165, particularly in unregulated settings, poses significant health risks. Adverse effects can include tachycardia, hypertension, hallucinations, and in severe cases, psychosis. The long-term health effects of synthetic cannabinoids like JWH-165 are not well understood, but they are considered to be potentially harmful.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• John W. Huffman
• Naphthoylindole