JWH-237

JWH-237 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-237 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its IUPAC name is 1-(2-(4-(1,1-dimethylheptyl)phenyl)ethyl)-3-(naphthalen-1-oyl)indole. The compound has a molecular formula of C₃₂H₃₇NO and a molecular weight of 451.64 g/mol.

The structure of JWH-237 includes a naphthoyl group attached to an indole core, with a 1,1-dimethylheptyl side chain. This structural configuration is crucial for its activity at the cannabinoid receptors.

Pharmacology

JWH-237 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is more associated with immune system modulation.

The binding affinity of JWH-237 to the CB1 receptor is in the low nanomolar range, indicating its high potency. This makes it significantly more potent than Δ9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status

The legal status of JWH-237 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, it is listed as a Schedule I substance under the Controlled Substances Act.

Potential Risks and Effects

As with other synthetic cannabinoids, JWH-237 can produce a range of effects, including euphoria, altered perception, and relaxation. However, it can also lead to adverse effects such as anxiety, paranoia, tachycardia, and in severe cases, psychosis or seizures.

The use of synthetic cannabinoids like JWH-237 is associated with significant health risks, particularly due to their high potency and the variability in product purity and composition.

Research and Applications

JWH-237, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. However, due to its potential for abuse, its use is restricted to controlled laboratory settings.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Naphthoylindole
• CB1 receptor
• CB2 receptor