JWH-241
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Chemical Data
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JWH-241 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-241 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its IUPAC name is 1-(2-(4-(1,1-difluoropentyl)-1H-indol-3-yl)ethyl)-3-(naphthalen-1-yl)urea. The compound has a molecular formula of C₃₀H₂₆F₂N₂O and a molecular weight of 408.49 g/mol.
Pharmacology[edit | edit source]
JWH-241 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₂ receptor. This receptor selectivity is of interest in research as it may lead to the development of compounds with therapeutic potential that have fewer psychoactive effects compared to traditional cannabinoids like THC.
Legal Status[edit | edit source]
The legal status of JWH-241 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it remains legal but may be subject to regulation under analog laws.
Research and Applications[edit | edit source]
JWH-241 has been used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. Its selective action on the CB₂ receptor makes it a candidate for studying immune system modulation and potential anti-inflammatory effects.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-241 is not well-established. There is limited data on its toxicity, potential for addiction, and long-term health effects. Users of synthetic cannabinoids have reported adverse effects such as anxiety, paranoia, and cardiovascular issues.
Also see[edit | edit source]
- Synthetic cannabinoids
- Cannabinoid receptor
- Endocannabinoid system
- JWH-018
- CB1 receptor
- CB2 receptor
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Contributors: Prab R. Tumpati, MD
