Phenelfamycin E

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Phenelfamycin E

Phenelfamycin E is a natural product and a member of the phenelfamycin family of antibiotics. It is produced by certain strains of the bacteria Streptomyces and has been found to exhibit potent antibacterial activity.

History

Phenelfamycin E was first isolated and identified in the late 20th century during a screening for new antibiotics. The compound was discovered in the culture broth of a Streptomyces strain, a genus of bacteria known for their prolific production of antibiotics.

Structure and Biosynthesis

Phenelfamycin E is a macrolide, a type of natural product characterized by a large macrocyclic lactone ring. The structure of phenelfamycin E also includes a unique sugar moiety, which is believed to contribute to its antibacterial activity.

The biosynthesis of phenelfamycin E involves a complex series of enzymatic reactions. The macrolide core is assembled by a polyketide synthase (PKS), a type of enzyme that builds complex molecules from simple building blocks. The sugar moiety is then attached by a glycosyltransferase, an enzyme that transfers sugar groups onto molecules.

Biological Activity

Phenelfamycin E has been found to exhibit potent antibacterial activity against a range of bacteria, including both Gram-positive and Gram-negative species. The compound is believed to work by inhibiting protein synthesis in bacteria, although the exact mechanism of action is not fully understood.

See Also

• Phenelfamycin
• Antibiotics
• Streptomyces
• Macrolide
• Polyketide synthase

References

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