(Redirected from Milophene)
Clomifene, also known as clomiphene, is a prodrug type medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome.
Mechanism of action of Clomifene[edit source]
Use results in a greater chance of twins.
It is taken by mouth once a day, with a course of treatment that usually lasts for 5 days.
FDA approval information for Clomifene[edit source]
Clomifene was approved for medical use in the United States in 1967.
WHO essential medicine list[edit | edit source]
It is on the World Health Organization's List of Essential Medicines, under the category Ovulation inducers (Complementary List).
Its introduction began the era of assisted reproductive technology.
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Estrogens and antiestrogens |
Estrogens |
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ER
agonists | * Steroidal: Alfatradiol
- Certain androgens/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, metandienone, nandrolone esters) (via estrogenic metabolites)
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Antiestrogens |
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antagonists (incl. SERMs
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Aromatase inhibitors | |
Antigonadotropins | * Androgens/ anabolic steroids (e.g., testosterone, testosterone esters, nandrolone esters, oxandrolone, fluoxymesterone)
- D2 receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)
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Others | * Mixed mechanism of action: Danazol
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Estrogen receptor modulators |
ER
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Agonists | * Steroidal: 2-Hydroxyestradiol
- 2-Hydroxyestrone
- 3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
- 3α-Androstanediol
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- 17α-Estradiol (alfatradiol)
- 17α-Dihydroequilenin
- 17α-Dihydroequilin
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- 17α-Ethynyl-3α-androstanediol
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- Lavender oil
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- Others (e.g., agnuside, rotundifuran)
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