Estrogen antagonist

Estrogen Antagonist

An Estrogen antagonist is a type of drug that inhibits the effects of estrogen in the body. These drugs are also known as anti-estrogens and are commonly used in the treatment of hormone receptor-positive breast cancer and other estrogen-related conditions.

Mechanism of Action

Estrogen antagonists work by binding to the estrogen receptor, thereby preventing estrogen from binding to these receptors. This inhibits the effects of estrogen in the body, which can slow the growth of certain types of cancer cells that require estrogen to grow.

Types of Estrogen Antagonists

There are two main types of estrogen antagonists: selective estrogen receptor modulators (SERMs) and aromatase inhibitors.

Selective Estrogen Receptor Modulators (SERMs)

Selective estrogen receptor modulators (SERMs) are a type of estrogen antagonist that bind to estrogen receptors and either block or activate the receptor depending on the tissue type. Examples of SERMs include tamoxifen and raloxifene.

Aromatase Inhibitors

Aromatase inhibitors are another type of estrogen antagonist. They work by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens to estrogens in the body. Examples of aromatase inhibitors include anastrozole, letrozole, and exemestane.

Uses

Estrogen antagonists are primarily used in the treatment of hormone receptor-positive breast cancer. They may also be used in the treatment of other conditions such as osteoporosis, infertility, and endometriosis.

Side Effects

Like all drugs, estrogen antagonists can have side effects. These may include hot flashes, vaginal dryness, mood changes, and an increased risk of blood clots and stroke. It is important to discuss these potential side effects with a healthcare provider before starting treatment.

See Also

• Estrogen
• Hormone receptor-positive breast cancer
• Selective estrogen receptor modulators (SERMs)
• Aromatase inhibitors