Fluoroestradiol F18

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What is Fluoroestradiol F18?[edit | edit source]

Fluoroestradiol f-18 is a Radioactive Diagnostic Agent.

What are the uses of Fluoroestradiol F18?[edit | edit source]

It is used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions.

How does Fluoroestradiol F18 work?[edit | edit source]

Fluoroestradiol F-18 is an analog of estradiol that emits small amounts of radioactivity, allowing it to be detected using PET. Following intravenous administration, it accumulates in cancerous tissues expressing estrogen receptors, thus allowing for visualization of these lesions. Fluoroestradiol has a relatively short duration of action - at 2 hours post-injection circulating levels are <5% those at peak concentration. The uptake of fluoroestradiol F-18 is not specific to breast cancer cells and make occur in any tumor cell expressing estrogen receptors, including those arising from the uterus or ovaries.

Does Fluoroestradiol F18 approved by FDA?[edit | edit source]

Fluoroestradiol F-18 was first granted FDA approval in May 2020, and will be developed by PETNET Solutions, Inc. and Zionexa USA under the brand name Cerianna. It is expected to be available in late 2020/early 2021.

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