Polyestriol phosphate
Polyestriol phosphate is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 3-(dihydrogen phosphate) ester of polyestriol – which is used in medicine. It is a long-acting and water-soluble form of polyestriol.
Pharmacology[edit]
As a phosphate ester of polyestriol, polyestriol phosphate is a prodrug of polyestriol that is stored in the body and is slowly hydrolyzed into polyestriol, which is the active form. The medication has a very long duration of action when given by intramuscular injection, and a single dose has a duration of about one month.
Medical uses[edit]
Polyestriol phosphate is used in the treatment of menopausal symptoms and osteoporosis in women. It has also been used to treat prostate cancer in men.
Side effects[edit]
Side effects of polyestriol phosphate are similar to those of other estrogens and include breast tenderness, breast enlargement, nausea, headache, and fluid retention.
Pharmacokinetics[edit]
Following an intramuscular injection of polyestriol phosphate, the medication is slowly absorbed into the bloodstream and is then slowly hydrolyzed into polyestriol, which is the active form.
History[edit]
Polyestriol phosphate was first described in the literature in 1957 and was introduced for medical use by 1960.
See also[edit]
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Polyestriol phosphate structure -
Estriol phosphate molecule model
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