Anti-CD25-PBD antibody-drug conjugate ADCT-301
Anti-CD25-PBD antibody-drug conjugate ADCT-301
An immunoconjugate consisting of a human immunoglobulin (Ig) G1 monoclonal antibody.
How does it work?[edit | edit source]
It is directed against the alpha subunit of the interleukin-2 receptor (IL-2R alpha or CD25) and conjugated, via a cleavable linker, to a synthetic, cross-linking agent pyrrolobenzodiazepine (PBD) dimer that targets DNA minor grooves, with potential antineoplastic activity.
Mechanism of action[edit | edit source]
- The monoclonal antibody portion of the anti-CD25 antibody-drug conjugate (ADC) ADCT-301 specifically binds to the cell surface antigen CD25.
- This causes the internalization of ADCT-301 and the subsequent release of the cytotoxic PBD moiety.
- The imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA.
- This induces interstrand cross-links in the minor groove of DNA and inhibits DNA replication, which inhibits the proliferation of CD25-overexpressing tumor cells.
CD25[edit | edit source]
CD25, a transmembrane receptor and tumor-associated antigen (TAA), is expressed on certain cancer cells.
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Contributors: Prab R. Tumpati, MD
