AllerNaze

What is AllerNaze?

• AllerNaze (triamcinolone acetonide) is a corticosteroid used for the treatment of the nasal symptoms of seasonal and perennial allergic rhinitis.

Triamcinolone acetonide

Triamcinolone acetonide (Ball-n-Stick)

What are the uses of this medicine?

• AllerNaze (triamcinolone acetonide) is a prescription medicine called a corticosteroid used to treat seasonal and year-round allergies in adults and children age 12 and older.
• When AllerNaze is sprayed in your nose, this medicine helps lessen the symptoms of sneezing, runny nose, and nasal itching associated with nasal allergies.

Allergic rhinitis:

• Allergic rhinitis is a condition that causes swelling and increased watery fluid in the nose and nasal passages. This can result in sneezing, runny nose, itching, and difficulty in breathing through the nose.
• This response is caused by an allergy to pollen that comes from many types of plants including trees, grasses, and weeds. Allergic responses of this type may also be caused by mold spores, house dust mites, animal dander, and other substances.

How does this medicine work?

• Triamcinolone acetonide is a more potent derivative of triamcinolone.
• Triamcinolone A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
• Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins.
• Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation.
• In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited.
• T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.

Who Should Not Use this medicine ?

This medicine cannot be used in patients:

• with a hypersensitivity to any of its ingredients.

What drug interactions can this medicine cause?

• No formal drug interaction studies have been conducted with AllerNaze.

Is this medicine FDA approved?

• It was approved for medical use in the United States in 2009.

How should this medicine be used?

Recommended dosage:

• The recommended starting dose of AllerNaze for most patients is 200 mcg per day given as 2 sprays (approximately 50 mcg/spray) in each nostril once a day.
• The maximum dose should not exceed 400 mcg per day.
• If the 400 mcg dose is used, it may be given either as a once a day dosage (4 sprays in each nostril) or divided into two daily doses of two sprays/nostril twice a day.

• After symptoms have been brought under control, patients should be titrated to the minimum effective dose to reduce the possibility of adverse effects.

Administration:

• Use AllerNaze on a regular schedule exactly as prescribed by your doctor
• Do not use more AllerNaze or take it more often than your doctor tells you. It usually takes several days to one week of regular use to feel the medicine working.
• Protect your eyes from the spray.
• If your symptoms do not improve, or if they become worse, contact your doctor.
• Do not stop taking AllerNaze without contacting your doctor.
• AllerNaze does not relieve the red and itchy eye symptoms that some people have with allergic rhinitis. Ask your doctor for advice on treatment.
• Tell your doctor if you have irritation, burning or stinging inside your nose that does not go away when using AllerNaze.
• You may have nosebleeds after using AllerNaze. If so, contact your doctor right away.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As metered-dose manual spray with 0.05% w/v triamcinolone acetonide

This medicine is available in fallowing brand namesː

• AllerNaze

What side effects can this medication cause?

The most common side effects of this medicine include:

• Headache
• Back Pain
• Pharyngitis
• Asthma
• Cough Increased
• Dyspepsia
• Nausea
• Vomiting
• Taste Perversion
• Conjunctivitis
• Myalgia

What special precautions should I follow?

• The replacement of a systemic corticosteroid with a topical corticosteroid can be accompanied by signs of adrenal insufficiency and, in addition, some patients may experience symptoms of corticosteroid withdrawal, e.g., joint or muscular pain, or both, lassitude and depression.
• Patients who are on immunosuppressant drugs are more susceptible to infections than healthy individuals. Chickenpox and measles, for example, can have a more serious or even fatal course in children or adults on immunosuppressant doses of corticosteroids.
• Intranasal corticosteroids may cause a reduction in growth velocity when administered to pediatric patients
• AllerNaze should be used with caution, if at all, in patients with active or quiescent tuberculous infection of the respiratory tract or in patients with untreated fungal, bacterial, or systemic viral infections or ocular herpes simplex.
• Because of the inhibitory effect of corticosteroids on wound healing, in patients who have experienced recent nasal septal ulcers, nasal surgery or trauma, a corticosteroid should be used with caution until healing has occurred.
• The bottle should be discarded after 120 sprays following initial priming since the amount of triamcinolone acetonide delivered thereafter per spray may not be consistent. Do not transfer any remaining solution to another bottle.
• Patients who experience recurrent episodes of epistaxis (nose bleeds) or nasal septum discomfort while taking this medication should contact their physician.

What to do in case of emergency/overdose?

Symptoms of overdosage may include:

• gastrointestinal upset
• Chronic overdosage with any corticosteroid may result in signs or symptoms of hypercorticism.

Management of overdosage:

• In the event of an overdose, appropriate supportive treatment should be initiated.

Can this medicine be used in pregnancy?

• There are no adequate and well-controlled studies in pregnant women.
• Triamcinolone acetonide, like other corticosteroids, should be used during pregnancy only if the potential benefits justify the potential risk to the fetus.

Can this medicine be used in children?

• Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

What are the active and inactive ingredients in this medicine?

Active ingredient:

• TRIAMCINOLONE ACETONIDE

Inactive ingredients:

• CITRIC ACID MONOHYDRATE
• EDETATE DISODIUM
• POLYETHYLENE GLYCOL 3350
• PROPYLENE GLYCOL
• SODIUM CITRATE
• BENZALKONIUM CHLORIDE
• WATER

Who manufactures and distributes this medicine?

• Lupin Pharma
• Baltimore, MD

What should I know about storage and disposal of this medication?

• Store between 68º to 77º F (20º to 25º C).
• Do not freeze.
• Use AllerNaze within 2 months after opening the protective foil pouch or before the expiration date on the box or label, whichever comes first.
• After using 120 sprays of AllerNaze throw the bottle away – the dose may not be accurate

• Dailymed label info on AllerNaze
• FDA AllerNaze

AllerNaze Resources
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