5-HT5A

5-HT5A is a subtype of the 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. This receptor is found in high concentrations in the cerebellum and hippocampus, suggesting a potential role in the modulation of memory and learning processes.

Function

The 5-HT5A receptor is one of the several different receptors for serotonin, a biogenic amine neurotransmitter. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. This receptor has been shown to function in part through the regulation of intracellular calcium levels.

Distribution

The 5-HT5A receptor is found in high concentrations in the cerebellum and hippocampus, suggesting a potential role in the modulation of memory and learning processes. It is also expressed in the cortex, amygdala, thalamus, and hypothalamus.

Clinical significance

The 5-HT5A receptor has been implicated in a variety of disorders including schizophrenia, depression, and anxiety. It is thought that modulation of this receptor may be beneficial in the treatment of these conditions.

Ligands

Several ligands have been discovered for the 5-HT5A receptor, including the antagonist SB-699551 and the agonist AS-19.

See also

• 5-HT receptor
• Serotonin
• G protein-coupled receptor

References

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