5-HT5A

5-HT5A is a subtype of the 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. This receptor is found in high concentrations in the cerebellum and hippocampus, suggesting a potential role in the modulation of memory and learning processes.

Function[edit | edit source]

The 5-HT5A receptor is one of the several different receptors for serotonin, a biogenic amine neurotransmitter. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. This receptor has been shown to function in part through the regulation of intracellular calcium levels.

Distribution[edit | edit source]

The 5-HT5A receptor is found in high concentrations in the cerebellum and hippocampus, suggesting a potential role in the modulation of memory and learning processes. It is also expressed in the cortex, amygdala, thalamus, and hypothalamus.

Clinical significance[edit | edit source]

The 5-HT5A receptor has been implicated in a variety of disorders including schizophrenia, depression, and anxiety. It is thought that modulation of this receptor may be beneficial in the treatment of these conditions.

Ligands[edit | edit source]

Several ligands have been discovered for the 5-HT5A receptor, including the antagonist SB-699551 and the agonist AS-19.

References[edit | edit source]

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5-HT5A Resources
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