N-Methyl-5-HT

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A chemical compound related to serotonin



N-Methyl-5-HT (N-Methylserotonin) is a chemical compound that is structurally related to the neurotransmitter serotonin. It is a member of the tryptamine family and acts as a selective agonist at certain serotonin receptors, particularly the 5-HT3 receptor.

Chemical Structure and Properties[edit | edit source]

N-Methyl-5-HT is a derivative of serotonin, where a methyl group is added to the nitrogen atom of the ethylamine side chain. This modification alters its pharmacological properties, making it a useful tool in scientific research to study the function of serotonin receptors.

Pharmacology[edit | edit source]

N-Methyl-5-HT is known for its selective agonism at the 5-HT3 receptor, a ligand-gated ion channel receptor. This receptor is involved in various physiological processes, including the modulation of neurotransmitter release, gastrointestinal motility, and the emetic response. N-Methyl-5-HT's action at the 5-HT3 receptor makes it valuable in research settings to understand the role of this receptor in different biological systems.

Receptor Selectivity[edit | edit source]

While N-Methyl-5-HT primarily targets the 5-HT3 receptor, it may also interact with other serotonin receptor subtypes, albeit with lower affinity. Its selectivity profile is crucial for distinguishing the specific contributions of 5-HT3 receptor activation in complex biological responses.

Applications in Research[edit | edit source]

N-Methyl-5-HT is used extensively in pharmacological studies to:

  • Investigate the role of 5-HT3 receptors in the central and peripheral nervous systems.
  • Explore the mechanisms of action of antiemetic drugs, which often target the 5-HT3 receptor to prevent nausea and vomiting.
  • Study the involvement of serotonin receptors in mood regulation, anxiety, and other neuropsychiatric conditions.

Safety and Handling[edit | edit source]

As with many research chemicals, N-Methyl-5-HT should be handled with care. Appropriate safety measures, including the use of personal protective equipment and adherence to laboratory safety protocols, are essential to prevent exposure and ensure safe handling.

Also see[edit | edit source]




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Contributors: Prab R. Tumpati, MD