5-HT6

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5-HT6 receptor

The 5-HT6 receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to G_s and mediates excitatory neurotransmission. The 5-HT6 receptor is expressed almost exclusively in the brain, and in particular in the striatum, nucleus accumbens, olfactory tubercle, and cortex, suggesting it plays a significant role in central nervous system (CNS) functions.

Function[edit | edit source]

The 5-HT6 receptor is thought to have a role in cognition and is being investigated for its potential to treat cognitive deficits, such as those seen in Alzheimer's disease. It has been shown to stimulate neurogenesis in the striatum and hippocampus, and to increase dendritic spine density in cortical neurons, suggesting a potential role in memory and learning.

Ligands[edit | edit source]

Several selective 5-HT6 ligands have been developed, including antagonists, agonists, and partial agonists. These have been used to investigate the receptor's function and potential as a drug target. Some of these ligands have shown promise in preclinical and clinical trials for the treatment of obesity, depression, schizophrenia, and Alzheimer's disease.

See also[edit | edit source]

References[edit | edit source]



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Contributors: Prab R. Tumpati, MD