CRL-40,941

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Chemical structure of CRL-40,941 (Fladrafinil)

CRL-40,941, commonly referred to as Fladrafinil, is a central nervous system stimulant drug that bears close structural and pharmacological similarity to adrafinil and modafinil. It is considered a bis(p-fluoro) ring-substituted derivative of adrafinil.

Pharmacodynamics

Fladrafinil acts as a central nervous system stimulant, but its exact mechanism of action remains not fully elucidated. It has been postulated that, much like its counterparts, it may modulate the release or reuptake of certain neurotransmitters, potentially affecting alertness and wakefulness.

Comparative Potency

The presence of the fluorine substitution in its molecular structure is believed to enhance the potency of CRL-40,941. Preliminary findings suggest that its potency might be approximately twice that of adrafinil, though this assertion requires further scientific validation.^{[citation needed]}

Behavioral Effects

Interestingly, animal studies have indicated that CRL-40,941 exhibits anti-aggressive properties. This behavior-modifying effect is not observed with adrafinil, highlighting a potential unique pharmacological profile for Fladrafinil.^{[citation needed]}

Recreational Use

By the end of 2013, CRL-40,941 had emerged on recreational drug markets. Its use in this context raises concerns related to safety, potential for misuse, and lack of comprehensive knowledge about its long-term effects on human health.

Safety and Regulation

The safety profile of CRL-40,941 is not as extensively studied as that of more established drugs like modafinil. Given its emergence on recreational drug markets, there is a pressing need for regulatory bodies to assess its safety, potential for abuse, and possible medicinal benefits.

See Also

• Adrafinil
• Modafinil
• Stimulant
• Nootropic