Methamphetamine
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Methamphetamine[edit | edit source]
Methamphetamine is a powerful, highly addictive central nervous system (CNS) stimulant drug that is chemically related to amphetamine. It is commonly known by several street names, including "meth," "crystal," "crystal meth," and "ice." Methamphetamine is primarily used recreationally for its euphoric effects, but it has also been prescribed in the past for medical purposes, such as treating attention deficit hyperactivity disorder (ADHD) and obesity. Due to its high potential for abuse and addiction, methamphetamine is classified as a Schedule II controlled substance in the United States.
History[edit | edit source]
Methamphetamine was first synthesized in 1919 by Japanese chemist Akira Ogata. It was initially used as a nasal decongestant and bronchodilator in the 1930s and 1940s. During World War II, methamphetamine was distributed to soldiers to combat fatigue and increase alertness. In the 1950s and 1960s, methamphetamine was prescribed as a treatment for obesity, ADHD, and narcolepsy. However, due to the growing awareness of its potential for abuse and addiction, its medical use became more restricted, and by the 1970s, it was classified as a controlled substance in many countries.
Effects[edit | edit source]
Methamphetamine produces a range of effects by increasing the release and blocking the reuptake of certain neurotransmitters, such as dopamine, norepinephrine, and serotonin. Some of the common effects of methamphetamine use include:
- Euphoria and a sense of well-being
- Increased energy and alertness
- Heightened concentration and focus
- Increased talkativeness
- Decreased appetite
- Increased libido
Methamphetamine use can also lead to negative side effects, such as:
- Anxiety, agitation, or paranoia
- Insomnia
- Rapid heart rate and increased blood pressure
- Dry mouth and dental problems, commonly known as "meth mouth"
- Skin picking and sores
- Weight loss and malnutrition
Risks and addiction[edit | edit source]
Methamphetamine is a highly addictive substance, and regular use can quickly lead to dependence and addiction. The drug's intense euphoric effects and the rapid development of tolerance contribute to its high addiction potential. Chronic methamphetamine use can have severe consequences, including:
- Cognitive impairments, such as memory loss and difficulty concentrating
- Psychiatric symptoms, such as paranoia, hallucinations, and mood disturbances
- Cardiovascular problems, such as heart attack, stroke, and irregular heartbeat
- Neurotoxicity and damage to dopamine-producing neurons
- Social and occupational difficulties, including job loss, relationship problems, and legal issues
Treatment[edit | edit source]
Treatment for methamphetamine addiction typically involves a combination of behavioral therapies, such as cognitive-behavioral therapy (CBT), contingency management, and the Matrix Model. These therapies focus on helping individuals develop coping skills to manage cravings, avoid triggers, and maintain sobriety. While there are currently no approved medications specifically for methamphetamine addiction, some research suggests that certain medications, such as naltrexone and bupropion, may be helpful in reducing cravings and promoting abstinence.
See also[edit | edit source]
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- Methamphetamine
- 1893 introductions
- Anorectics
- Aphrodisiacs
- Attention deficit hyperactivity disorder management
- Carbonic anhydrase activators
- Cardiac stimulants
- Euphoriants
- Excitatory amino acid reuptake inhibitors
- Japanese inventions
- Management of obesity
- Norepinephrine-dopamine releasing agents
- Phenethylamines
- Sigma agonists
- Stimulants
- Substituted amphetamines
- Sympathomimetics
- TAAR1 agonists
- VMAT inhibitors
Contributors: Prab R. Tumpati, MD